| 摘要: |
| ［摘要］目的 探讨2型糖尿病（T2-DM）患者双下肢动脉粥样硬化（lower extremity atherosclerosis，LEA）程度与骨密度（BMD）改变的相关性．方法 通过对219 例T2-DM 患者，运用多普勒彩色超声仪进行双下肢动脉检查，根据超声检查的LEA评分及病变程度将T2-DM 患者分为无病变（65例）、轻度病变（62例）、中度病变（56例）和重度病变（36例）4组，通过双能X线骨密度仪测定腰椎和股骨的BMD，观察分析不同组间的临床因素及生化指标，探讨LEA改变与骨密度之间的关系．结果 （1） 随着LEA程度的加重，HBA1c、FBG、2HPBG、TC、TG、LDL逐渐升高，HDL逐渐下降，差异有统计学意义 （P＜0.05）；（2）LEA程度评分与所检查的腰椎和股骨的BMD均呈负相关（P＜0.05 ）；（3）进一步Logistic回归分析显示BMD改变、HBA1c 、TC是T2-DM 患者LEA的主要危险因素．结论 T2-DM患者中LEA程度越严重，其BMD下降越明显，BMD的下降是LEA发生和发展的危险因素． |
| 关键词: ［关键词］2型糖尿病 下肢动脉 动脉粥样硬化 |
| DOI： |
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| The Correlation between Lower Extremity Atherosclerosis and Bone Mineral Density in Type 2 Diabetes Mellitus Patients |
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WANG Ling
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| Abstract: |
| ［Abstract］Objective To explore the correlation between lower extremity atherosclerosis（LEA）and bone mineral density in type 2 diabetes mellitus（T2-DM）patients．Methods Two hundred and nineteen T2-DM were enrolled in this study．Severity of LEA was examined by Doppler Ultrasound of Aloka -α 10（Japan）. According to severity of LEA score，the subjects were divided into the control（n＝65），mild（n＝62），moderate （n=56）and severe（n=36） groups. The bone mineral density （BMD）in lumbar vertebrate and femoral bone was measured by Dual-energy X-ray absorptiometry（ DEXA）made in America．The clinical factors and biochemical parameters of patients in different groups were observed and the correlation between lower extremity atherosclerosis and bone mineral density．Results（1） With the increase in the severity of LEA，the HBA1c，FBG， 2HPBG， TC， TG and LDL were gradually increased ，but HDL was decreased in the four groups， there was significant differences（P＜0.05）.（2）The severity score of LEA was negative correlated with the BMD in lumbar vertebrat and femoral bone.（3）Multivariate Logistic regression analysis showed the change of BMD，HBA1c and TC were major risk factors of LEA T2-DM .Conclusions With the increase in the severity of LEA in T2-DM，the decrease of BMD is more obvious．The decrease of BMD is a risk factor of LEA production and development． |
| Key words: ［Key words］Type 2 diabetes mellitus Artery of lower extremity Atherosclerosis |