| 摘要: |
| ［摘要］目的 探讨高迁移率族蛋白B1（HMGB1）与大鼠急性胰腺炎模型病情严重程度关系．方法 制作大鼠重症急性胰腺炎A组、轻症急性胰腺炎B组、正常对照组C组模型各10只，于造模后12 h、24 h、48 h采血，采用酶联免疫法（ELISA）检测各组大鼠模型不同时间段血清HMGB1含量的变化．结果 大鼠血清HMGB1在各时间点测量值A组高于B组高于C组，P＜0.05，具有统计学意义．结论 大鼠血清HNGB1与急性胰腺炎的病情严重程度成正相关． |
| 关键词: ［关键词］高迁移率族蛋白B1 大鼠急性胰腺炎模型 病情严重程度． |
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| The Relationship between HMGB1 and Serious Degree of Acute Pancreatitis in Rats |
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LONG Kui
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| Abstract: |
| ［Abstract］Objective To explore the relationship between high mobility race protein B1（HMGB1）and serious degree of acute pancreatitis in rats．Methods Acute pancreatitis model in rats was established. Rats were divided into 3 groups: group A （severe acute pancreatitis group），group B（mild acute pancreatitis group），and group C（normal control group），and 10 rats in each group．Blood samples of rats in 3 groups were collected at 12 h，24 h and 48 h after establishing model，and the serum levels of HMGB1 were detected by enzyme linked immunosorbent assay（ELISA）．Result The serum levels of HMGB1 of rats in group A were higher than group B，and in group B were higher than group C at different time points，the difference had statistical significance（P＜0.05）．Conclusion The serum levels of HMGB1 are positively related with the serious degree of acute pancreatitis. |
| Key words: ［Key words］High mobility race protein B1 Acute pancreatitis models in rats Serious degree of acute pancreatitis |