| 摘要: |
| ［摘要］目的 探讨奈达铂同期放化疗治疗局部晚期宫颈癌的疗效和毒副反应．方法 35例患者采用每周奈达铂30 mg/m2同期放化治疗，放疗的当天开始于每周静脉用药1 d，共用5周；放疗方法：采用直线加速器6Mev-X线行盆腔大野照射DT 30 Gy后改为盆腔四野照射DT 20 Gy，总剂量DT 50 Gy；于放疗第4周开始每周行后装治疗2次，DT 600 cGy/次，共7次，A点剂量达4 200 cGy，观察疗效和不良反应． 结果 奈达铂放化总有效率89％，95%CI0.089%～0.939%，临床获益率89％，95%CI0.086%～0.936%；随访24个月无进展生存率（PFS）和总生存率（OS）分别为80％和94％，95%CI0.072%～0.948%．结论 奈达铂同期放化疗效可靠，毒副反应安全可耐受． |
| 关键词: ［关键词］局部晚期宫颈癌 奈达铂 同期放化疗 |
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| The Curative Effect of Nedaplatin Concurrent Chemotherapy and Radiotherapy on Local Advanced Cervical Cancer |
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WANG Xiao－li
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| Abstract: |
| ［Abstract］Objective To investigate the effect and toxicity of nedaplatin concurrent chemotherapy and radiotherapy on local advanced cervical Cancer．Methods The nedaplatin was given at a dose of 30 mg（m2.w） once a week for 5 weeks in 35 patients. External radiotherapy was given at a dose 30 Gy firstly and then was irradiated for another 20 Gy under the condition of A point by linear accelerator 6Mev-X， the total radiotherapy dose was 50 Gy. From the 4th week post radiotherapy， intracavitary irradiation at DT 600cGy/time was given for twice a week， and lasted for 7 times to a total dose 4 200 cGy for A point. The curative effect and adverse reactions were observed．Results The total effective rate and clinical benefits rate were both 89％．The 24 months disease-free survival and overall survival rate was 80％and 94％， respectively．Conclusion Nedaplatin concurrent chemotherapy and radiotherapy can get better effects and tolerated side-effects |
| Key words: ［Key words］Local advanced cervical cancer Nedaplatin Concurrent chemotherapy and radiotherapy |