| 摘要: |
| ［摘要］目的 探讨心肌脂肪酸结合蛋白（H-FABP）联合简化肺栓塞严重指数（sPESI）评估血液动力学稳定的急性肺栓塞（APE）短期预后的临床价值．方法 纳入130例血液动力学稳定APE患者，测定H-FABP和进行sPESI评分．结果 13例（10.0%）患者出现30 d不良事件．H-FABP［OR， 4.96（1.70-14.42），P＝0.003］与sPESI ［OR，9.50（2.24-40.28），P＝0.002］是血液动力学稳定的APE短期预后的预测因子．30例H-FABP＜6 μg/L且sPESI 0分组的患者，无1例出现30 d不良转归．H-FABP≥6 μg/L联合sPESI≥1分对血液动力学稳定APE患者的30 d预后的预测敏感度和阴性预测值均为100%．结论 H-FABP和sPESI能有效预测血液动力学稳定的APE患者短期预后，H-FABP联合sPESI能提高短期预后的预测敏感性，尤其有助于识别低危APE患者． |
| 关键词: ［关键词］肺栓塞 预后 心肌脂肪酸结合蛋白 简化肺栓塞严重指数 |
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| 基金项目:［基金项目］云南省教育厅科学研究基金资助项目（2012C019） |
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| Combination of Heart-type Fatty Acid-binding Protein and Simple Pulmonary Embolism Severity Index for the Assessment of the Short-term Prognosis in Patients with Acute Pulmonary Embolism |
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WU Wen－juan
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（The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China）
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| Abstract: |
| ［Abstract］Objective To evaluate the short-time prognostic value of combination of Heart-type fatty acid-binding protein (H-FABP) and simple Pulmonary Embolism Severity Index (sPESI) in normotensive patients with acute pulmonary embolism (APE). Methods One hundred and thirty normotensive patients with APE were enrolled. The plasma concentration of H-FABP was analyzed and the sPESI scores were calculated．Result 13(10%) patients had adverse 30-day outcome. The H-FABP［OR, 4.96（1.70-14.42），P = 0.003］and sPESI ［OR, 9.50（2.24-40.28），P = 0.002］were predictors for short-term prognosis of normotensive APE. All of the 30 patients (23.1%) with sPESI score 0 and H-FABP＜6 μg/L had no adverse 30-day outcome. The combination model of H-FABP ≥6 μg/L with sPESI≥1 point(s) was associated with increased prognostic sensitivity and negative predictive value, which both reached 100%．Conclusions The H-FABP assay and the sPESI are useful prognostic indicators for 30-day outcome of normotensive APE. The combination of the both predictors can yield additive prognostic information and particularly identify low-risk patients with APE. |
| Key words: ［Key words］Pulmonary embolism Prognosis Heart-type fatty acid-binding protein Simple pulmonary embolism severity index |