| 摘要: |
| ［摘要］ 目的 比较宫颈环形电刀切除术（loop electrosurgical excision procedure，LEEP）与传统冷刀锥切术（cold knife conization，CKC）对宫颈上皮内瘤变（cervical intraepithelial neoplasia；CIN）治疗的临床效果．方法 选取2012年5月至2014年5月解放军第一八七中心医院收治的86例CIN患者为研究对象，根据手术方法不同分为观察组和对照组．观察组患者43例，采用宫颈环形电刀切除术治疗；对照组患者43例，采用传统冷刀锥切术进行治疗；比较2组患者的临床疗效、病理变化及并发症情况．结果 观察组手术时间、术中出血量、住院时间及伤口愈合时间均明显少于对照组，2组差异均具有统计学意义（P＜0.05）；观察组手术前后病理分型一致率为79.07%，对照组为86.05%，2组手术前后病理分型一致率比较，差异无统计学意义（P＞0.05）；术后并发症方面，观察组术后并发症发生率为4.65%，对照组为16.27%，差异有统计学意义（P＜0.05）；2组患者术后疗效相当，治愈率、残留率及复发率，差异无统计学意义（P＞0.05）．结论 宫颈环形电刀切除术是诊治CIN的有效方法，能够缩短手术时间、住院时间及伤口愈合时间，减少术中出血量及并发症等，值得临床推广应用． |
| 关键词: ［关键词］ 宫颈环形电刀切除术 冷刀锥切术 宫颈上皮内瘤变 |
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| 基金项目:［基金项目］ 国家临床重点专科建设基金资助项目（卫规财函2011-1） |
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| The Clinical Value of Loop Electrosurgical Excision Procedure in Treating Cervical Intraepithelial Neoplasia |
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LI Yi－mei1,2
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1.（1）Dept. of Obstetrics and Gynecology，The 187th Military Center Hospital，Haikou Hainan 571159;2.２）Dept. of Gynaecology，West China Second Hospital，Sichuan University，Chengdu Sichuna 610000，China）
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| Abstract: |
| ［Abstract］Objective To compare the clinical effect of loop electrosurgical excision procedure（LEEP） and cold knife conization（CKC） on treating patients with cervical intraepithelial neoplasia（CIN）. Methods Eighty-six patients with CIN treated in our hospital during May 2012 and May 2014 were enrolled in this study. The patients were divided into observation group and control group depending on the surgical treatment. Forty-three patients in observation group were treated with LEEP and 43 patients in control group were treated with traditional CKC. The clinical efficacy，change of pathology and complications of two groups were compared. Results The operative time， blood loss，hospitalization time and healing time of observation group were significantly lower than those of control group （P＜0.05）. The consistent rate of pathological and colposcopy biopsy in observation group was 79.07% and 86.05% in control group， there was no significant difference between two groups（P＞0.05）. The incidence of complications of observation group was 4.65%， which was significantly lower than 16.27% of control group（P＜0.05）. Two groups had same values in treatment effect， there were no significant differences in cure rate， residue rate and recurrence rate（P＞0.05）. Conclusions LEEP is an effective method for treating CIN. Compared with CKC， LEEP has shorter operation time， hospitalization time and healing time; also has lower intraoperative blood loss and incidence of complications. It has high clinical value and worth of popularization and application. |
| Key words: ［Key words］Loop electrosurgical excision procedure Cold knife conization Cervical intraepithelial neoplasia |