| 摘要: |
| ［摘要］ 目的 探讨结核药联合利福喷丁对肺结核患者免疫功能、炎症因子、VEGF及MMP-9的影响．方法 60例肺结核患者按照随机分组法分为对照组（n＝30）和观察组（n＝30）．对照组采用利福喷丁治疗，观察组在对照组基础上结合结核丸治疗．对比分析2组治疗前和治疗6个月后免疫功能、炎症因子、VEGF及MMP-9水平变化．结果 治疗后，2组组CD3+、CD4+、CD4/CD8均较治疗前显著增加（P＜0.05）；治疗后，观察组CD3+、CD4+、CD4/CD8明显高于对照组（P＜0.05）；与治疗前相比，2组治疗后INF-γ水平均明显增加（P＜0.05），IL-4、CRP、TNF-α水平明显降低（P＜0.05）；与对照组治疗后相比，观察组INF-γ水平明显较高（P＜0.05），而IL-4、CRP、TNF-α水平较低（P＜0.05）；与治疗前相比，2组治疗后血清MMP-9、VEGF水平明显降低（P＜0.05）；与对照组治疗后相比，观察组血清MMP-9、VEGF水平明显降低（P＜0.05）．结论 结核药联合利福喷丁可明显改善患者免疫功能、降低炎症反应、降低VEGF及MMP-9水平，从而有效控制病情，具有重要研究意义，值得进一步推广应用． |
| 关键词: ［关键词］ 结核药 利福喷丁 肺结核 免疫功能 炎症因子 VEGF和MMP-9 |
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| 基金项目:［基金项目］ 广东省医学科研基金资助项目（A2012438） |
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| Effects of Tuberculosis Drugs Combined with Rifapentine on the Immune Function， Inflammatory Factors， VEGF and MMP-9 of TB Patients |
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HONG Xu－hua1,2
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1.（1）Dept. of Respiratory Medicine，Xishui People’s Hospital of Hubei Province，Xishui Hubei 438200;2） Dept. of Respiratory Medicine，Affiliated Hospital of Guangdong Medical College，Zhanjiang Guangdong 524001，China）
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| Abstract: |
| ［Abstract］Objective To investigate the effects of TB drugs combined with rifapentine on the immune function， inflammatory factors，VEGF and MMP-9 of patients with pulmonary tuberculosis. Methods Sixty cases of tuberculosis patients were randomly divided into control group（n = 30） and observation group （n = 30）. The control group was given rifapentine，while the treatment group was given tuberculosis pill treatment based on rifapentine. The immune function， inflammatory factors，VEGF and MMP-9 levels of patients before and six months after treatment between the two groups. Results After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the two groups were increased significantly（P＜0.05）. After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the observation group were significantly higher than those in the control group（P＜0.05）. Compared with before treatment， after treatment INF-γ levels were significantly increased（P＜0.05）， IL-4， CRP， TNF-α levels were significantly lower （P＜0.05）. Compared to the control group after treatment and observation Group INF-γ levels were significantly higher （P＜0.05）， while IL-4， CRP， TNF-α levels lower（P＜0.05）. Compared with before treatment， the serum MMP-9， VEGF levels were significantly lower after treatment （P＜0.05）. Compared with the control group， the serum MMP-9， VEGF levels of patients in the observation group were significantly lower after treatment（P＜0.05）. Conclusions Tuberculosis drug combined with rifapentine can significantly improve the immune function of TB patients， reduce inflammation， reduce VEGF and MMP-9 levels， so as to effectively control the disease， has important significance， and is worthy of further application. |
| Key words: ［Key words］Tuberculosis drug Rifapentine Tuberculosis Immune function Inflammatory factor VEGF and MMP-9 |