| 摘要: |
| ［摘要］ 目的 探讨血浆纤维蛋白原及D-二聚体对进展性脑卒中的诊断价值．方法 2014年1月至2015年5月期间，河北邢台市第三医院40例进展性脑卒中患者（A组）和40例完全性脑卒中患者（B组），以及80例健康体检者（C组），作为研究对象，A组和B组于入院24 h、3 d、7 d、14 d，检测和比较血浆纤维蛋白原（FIB）及D-二聚体（DD）水平，以及入院后NIHSS评分变化情况．结果 与C组相比，A组入院24 h、入院3 d、入院7 d，FIB水平明显增高，B组入院24 h、入院3 d，FIB水平明显增高，P＜0.05；与B组相比，A组入院24 h、入院3 d、入院7 d，FIB水平明显增高，P＜0.05；A组FIB水平在入院3 d达峰，入院7 d开始降低，入院14 d基本降至正常，而B组FIB水平在入院24 h逐渐达峰，入院3 d开始降低，入院7 d基本降至正常．与C组相比，A组入院24 h、入院3 d、入院7 d DD水平明显增高，B组入院24 h、入院3 d DD水平明显增高，P＜0.05；与B组相比，A组入院24 h、入院3 d、入院7 d DD水平明显增高，P＜0.05；A组DD水平在入院24 h开始进行性增高，入院7 d达峰，入院14 d基本降至正常，而B组DD水平在入院24 h逐渐增高，入院3 d达峰，入院7 d基本降至正常．与B组相比，A组入院3 d、入院7 d、入院14 d，NIHSS评分均明显降低，P＜0.05．结论 监测血浆纤维蛋白原及D-二聚体变化，有助于进展性脑卒中的早期预测，并且进展性脑卒中患者机体处于更为明显的高凝状态． |
| 关键词: ［关键词］ 纤维蛋白原 D-二聚体 进展性脑卒中 诊断价值 |
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| 基金项目:［基金项目］ 河北省卫生厅医学科研基金资助项目（20130918010） |
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| The Diagnostic Value of Plasma Fibrinogen and D-dimer for the Progressive Stroke |
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JIA Liang1,2,3,4
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1.（1）Dept. of Rehabilitation;2）Dept. of Radiology;3）Department of Clinical Laboratory，Hebei Xingtai Third Hospital，Xingtai Hebei 054000;4）Dept. of Internal Medicine-Neurology，Hebei Baoding First Central Hospital，Baoding Hebei 071000，China）
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| Abstract: |
| ［Abstract］Objective To study the diagnostic value of plasma fibrinogen （FIB） and D-dimer （DD） for the progressive stroke．Methods The 40 patients with progressive stroke，40 patients with complete stroke， and 80 cases of health examination Hebei Xingtai Third Hospital our hospital from Jan 2014 to May 2015 were respectively regarded as the subjects of A group， B group， and C group，respectively. On 24h，3d，7d and 14d after admission，the plasma fibrinogen and D-dimer levels in all groups were detected and compared，the NIHSS scores in A group and B group were compared after admission. Results Compared with C group， the FIB levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）；compared with B group， the FIB levels on 24h， 3d， 7d were significantly increased in A group（P＜0.05）；the FIB levels reached to the peak on 3d after admission，began to decrease on 7d after admission， and basically returned to normal on 14d after admission in A group. The FIB levels were gradually admitted to the peak on 24h after admission，began to decrease on 3d after admission， and basically returned to normal on 7d after admission in B group. compared with C group，the DD levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）; compared with B group，the DD levels on 24h， 3d，7d were significantly increased in A group （P＜0.05）; the DD levels gradually increased on 24h after admission， were admitted to the peak on 7d after admission， and basically returned to normal on 14d after admission in A group. The DD levels gradually increased on 24h after admission，reached to the peak on 3d after admission， and basically returned to normal on 7d after admission in B group；compared with B group，the NIHSS scores on 3d，7d，14d after admission were significantly reduced in A group（P＜0.05）. Conclusion The monitoring of plasma fibrinogen and D-dimer can help for the early prediction of progressive stroke. |
| Key words: ［Key words］Fibrinogen D-dimer Progressive stroke Diagnosis value |