| 摘要: |
| ［摘要］目的 探讨E-cadherin和Vimentin在肝内胆管癌的表达与临床病理特征和预后关系．方法 采用免疫组化检测E-cadherin和Vimentin在50例肝内胆管癌及其癌旁肝内胆管组织中的表达，并分析与其临床病理特征和预后的关系．结果 在肝内胆管癌中E-cadherin的高表达率（42%）明显低于癌旁肝内胆管（68%），肝内胆管癌中Vimentin高表达率（50%）明显高于与癌旁肝内胆管（30%），差异有统计学意义（P＜0.05）．肝内胆管癌中E-cadherin的表达下降和Vimentin的表达上升均与TNM分期、肿瘤的分化、淋巴结转移及不良预后相关（P＜0.05）．结论 肝内胆管癌E-cadherin降低和Vimentin增加，与侵袭、转移以及不良预后密切相关，对判断病人预后有指导意义． |
| 关键词: ［关键词］肝内胆管癌 E-钙黏蛋白 波形蛋白 上皮-间充质转化 |
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| 基金项目:［基金项目］云南省应用基础研究基金资助项目（2011FZ124）；云南省科技厅-昆明医科大学联合专项基金项目（U0120140011） |
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| Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma |
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KANG Qiang
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（Dept. of Hepatpbiliary Surgery，The 2nd Affliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China）
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| Abstract: |
| ［Abstract］Objective To discuss the relationship between the expression of E-cadherin and Vimentin and pathological characteristics in intrahepatic cholangiocarcinoma（ICC）. Methods The expression of E-cadherin and Vimentin was detected by immunohistochemistry in ICC and para-carcinoma intrahepatic bile duct（n＝50）.The correlation between the expression of tumor tissues and the clinicopathological characteristics of ICC was analyzed， and their prognostic implication was evaluated. Results The expression of E-cadherin was significantly lower in ICC than in matched as the upper mentioned tissues （42%vs68%，P＜0.05）.The expression of Vimentin was significantly higher in intrahepatic cholangiocarcinoma （ICC） than matched as the upper mentioned tissues（50%vs30%，P＜0.05）. Down-regulation of E-cadherin and up-regulation of Vimentin were significantly associated with TNM stage，differentiation，lymph node metastasis of ICC （P< 0.05）.For the survival analyses，low E-cadherin expression and positive Vimentin expression were significantly associated with shorter survival（P＜0.05）．Conclusion Low expression of E-cadherin and high expression of Vimentin in the intrahepatic cholangiocarcinoma（ICC）are correlated with the invasion， migration and poor prognosis， and have clinical significance in judging the prognosis of patients. |
| Key words: ［Key words］Intrahepatic cholangiocarcinoma E-cadherin Vimentin EMT |