| 摘要: |
| ［摘要］目的 探讨CDH13基因变异与非小细胞肺癌（non-small cell lung cancer，NSCLC）的相关性．方法 采用TaqMan探针基因分型方法对NSCLC 患者（n＝115）及健康体检人群（n＝110）CDH13基因 rs11646213及rs7195409 2个单核苷酸多态性（single nucleotide polymorphism，SNPs）位点进行基因分型，评估上述2个SNPs与NSCLC 发生发展的相关性．结果 CDH13基因SNP- rs16146213基因型和等位基因频率在病例组和对照组中的分布均存具有统计学意义（P＜0.05）（OR＝0.464，95% CI：0.273～0.789）．SNP-rs7195409基因型和等位基因频率在不同临床分期中的分布均有统计学意义（P＜0.05）（OR＝0.491，95% CI：0.243～0.991）．结论 CDH13基因SNP-rs11646213与NSCLC的发生相关性，G等位基因对NSCLC的发生可能具有保护性作用．CDH13基因SNP-rs7195409与NSCLC 的恶性程度有关，G等位基因可能在NSCLC的发展中起到保护性作用． |
| 关键词: ［关键词］非小细胞肺癌 CDH13 单核苷酸多态性 |
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| 基金项目:［基金项目］云南省卫生科技计划项目（2014NS193）；云南省应用基础研究基金资助项目（2012FB064）；高等学校博士学科点专项科研基金资助项目（20111106120056） |
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| The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer |
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HONG Chao1,2,3
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1.（1）Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College， Kunming 650118;2）Dept. of Geriatrics，The No.1 Affiliated Hospital of Kunming Medical University， Kunming 650032;3）Dept. of Thoracic Surgery，The No.3 Affiliated Hospital of Kunming Medical University，Kunming 650118，China）
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| Abstract: |
| ［Abstract］Objective To evaluate the correlation of the single nucleotide polymorphisms （SNPs） in CDH13 with non-small cell lung cancer （NSCLC）. Methods 115 patients with NSCLC and 110 healthy controls were included in present study. Two SNPs （rs11646213 and rs7195409） in CDH13 were genotyped using TaqMan method. The association of these two SNPs with NSCLC was calculated and assessed. Results The genotypic and allelic frequencies of rs11646213 showed significant difference between NSCLC patients and the control group （P＜0.05），（OR＝0.464，95% CI：0.273～0.789）. The genotypic and allelic frequencies of rs7195409 showed significant difference between the stage I+II and stage III+IV groups （P＜0.05），（OR＝0.491，95% CI：0.243～0.991）. Conclusions The rs16146213 has a strong association with NSCLC and G allelic showed a protective effect. The rs7195409 has a strong association between stage I+II and III + IV in NSCLC， and G allele may play a protective role in the development of NSCLC. |
| Key words: ［Key words］Non-small cell lung cancer CDH13 Single-nucleotide polymorphisms |