| 摘要: |
| ［摘要］目的 研究腹腔镜联合孕三烯酮对卵巢子宫内膜异位囊肿的临床效果及预后．方法 采用随机、对照、前瞻性研究方法，选取2012年8月至2014年8月米易县人民医院诊治的卵巢子宫内膜异位囊肿患者78例，随机分为观察组和对照组，每组39例，观察组患者采用腹腔镜联合孕三烯酮（2.5mg/次，2次/周，连续服用6月）干预；对照组采用单纯腹腔镜术干预．比较2组术后6月血清卵泡刺激素（follicle stmi ulating hormone， FSH）和雌二醇（Estradiol E2）水平、卵巢最大平面平均直径（D）， MMP-9水平、TIMP-1水平、并随访术后18个月妊娠结局、复发率．结果 术后6月观察组改善E2和FSH明显优于对照组，差异有统计学意义（P＜0.01）；观察组术后改善血清MMP-9和TIMP-1水平明显优于对照组，差异有统计学意义（P＜0.01）；观察组术后D≤2 cm20例，D>2 cm19例，卵巢缩小比率51.28%；对照组D≤2 cm 5例，D>2 cm 34例，卵巢缩小比率12.82%，观察组卵巢缩小比率明显高于对照，差异有统计学意义（P＜0.01）；随访18月观察组复发率5.13%，对照组25.64%，观察组明显低于对照组，差异有统计学意义（P＜0.05）；观察组妊娠率66.66%，对照组30.77%，观察组明显高于对照组，差异有统计学意义（P＜0.01）．结论 腹腔镜术后采用孕三烯酮对卵巢子宫内膜异位囊肿患者预后保护卵巢功能、提高妊娠结局、减少复发率均有临床应用价值． |
| 关键词: ［关键词］腹腔镜 孕三烯酮 卵巢子宫内膜异位囊肿 临床效果 |
| DOI： |
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| 基金项目:［基金项目］广东省大学生创新实验计划基金资助项目（1212112009） |
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| Clinical Effect of Laparoscopy Combined with Gestrinone in Treatment of Ovarian Endometriosis Cyst and the Prognosis of Patients |
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ZHAO Xia1,2
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1.（1）Dept. of Obstetrics and Gynecology，The People’s Hospital of Miyi County，Panzhihua City，Sichuan Province，Panzhihua Sichuan 617200;2 ）Second Clinical Medical College of Southern Medical University ，Guangzhou Guangdong 510515，China）
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| Abstract: |
| ［Abstract］Objective To study clinical effect of laparoscopy combined with gestrinone in treatment of ovarian endometriosis cyst and the prognoisi of patients. Methods A randomized， controlled， prospective study was used in this study， 78 patients with ovarian endometriosis cyst were selected in Sichuan province panzhihua city miyi people's hospital from august 2012 to august 2014， and were randomly divided into observation group and control group， 39 patients in each group. Patients in the observation group were treated with laparoscopy combined with gestrinone （2.5 mg/time， two times per week， for 6 months） intervention; patients in the control group were treated with laparoscopic intervention. After six months， the postoperative serum FSH （Follicle Stmi Ulating Hormone， FSH）， Estradiol （E2） and Estradiol levels， ovarian biggest plane average diameter （D）， the level of MMP-9 and TIMP -1 level， pregnancy outcome of two groups were compared and the outcome and the recurrence rate 18 months after treatment were followed up. Results Six months after treatment， the E2 and FSH levels in the observation group were better than control group， with statistically significant difference （P＜0.01）；the postoperative serum levels of MMP-9 and TIMP-1 in Observation group were better than control group， with statistically significant difference （P＜0.01）; there were 20 patients of D≤2 cm， 19 patients of D>2 cm， the postoperative ovarian shrink rate was 51.28% in the observation group; there were 5 patients of D≤2 cm， 34 patients of D>2 cm ovarian shrink ratio was 12.82% in the control group， the ovarian shrink ratio of observation group was obviously higher than control group，with statistically significant difference （P＜0.01）. Follow-up for 18 months， the recurrence rate was 5.13% in the observation group，which was significantly lower than thatin the control group（25.64%），with statistically significant difference（P＜0.05）; the pregnancy rate was 66.66% and 30.77% in the Observation group and control group， respectively，the difference had statistical significance（P＜0.01）. Conclusion Laparoscopic surgery combined with gestrinone can protect ovarian function of patients with ovarian endometriosis cyst，improve pregnancy outcomes， and reduce recurrence rate， and has good clinical value. |
| Key words: ［Key words］Laparoscope Gestrinone Ovarian endometriosis cyst Clinical effect |