| 摘要: |
| ［摘要］目的 探讨云南汉族原发性高血压（EH）患者ACE基因多态性与厄贝沙坦降压疗效相关性．方法 选择100例1～2级原发性高血压患者，PCR 检测基因多态性，厄贝沙坦150 mg，每日1次降压治疗4周后评估降压疗效．结果 厄贝沙坦降压疗效在不同基因型中具有差异性，降压疗效DD型＞ID型＞II型，差异有统计学意义（P＜0.05）．结论 不同基因型对ARB药物治疗反应性具有差异性，基因多态性可能是影响个体对药物治疗反应的遗传因素． |
| 关键词: ［关键词］云南 汉族 原发性高血压 ACE基因 基因多态性 厄贝沙坦 降压疗效 |
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| 基金项目:［基金项目］云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2013FB202）；云南省教育厅科学研究基金资助项目（2013C211）；云南省卫生和计划生育委员会内设研究机构科研项目（2016NS201） |
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| The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients |
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HUANG Hong1,2,3
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1.（1）Dept. of Gerontology，First People’s Hospital of Yunnan Province，Kunming Yunnan 650032;2）Experiment Center for Medical Science Research，Kunming Medical University，Kunming Yunnan 650500;3）The Second People’s Hospital of Dehong，Dehong Yunnan 678400，China）
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| Abstract: |
| ［Abstract］Objective To analyze the correlationship of ACE I/D gene polymerphisms with the anti-hypertensive efficacy of irbesartan among essential hypertension（EH） patients in Yunnan han people. Methods One hundred EH patients hypertension were treated with irbesartan 150mg once daily for 4 weeks， and anti-hypertensive efficacy were monitored during the treatment. Results There was a significant difference between anti-hypertensive efficacy of irbesartan among different genotype groups， DD group＞ID group＞II group（P ＜0.05）．Conclusions There is different therapy responsiveness in diffenent genotypes. ACE I/D polymorphism may be an important hereditary factor that impacts the efficacy of irbesartan. |
| Key words: ［Key words］Yunnan Han ethnic Essential hypertension ACE gene Gene polymorphism Irbesartan Efficacy |