| 摘要: |
| ［摘要］目的 探讨应用昆明医科大学第二附属医院256排螺旋CT 灌注技术研究行颅骨修补手术前后脑血流的变化，评价颅骨修补术对颅骨缺损患者的脑组织血流灌注的影响．方法 应用256排螺旋CT做脑灌注扫描20例早期行颅骨修补手术患者在实施颅骨修补前手术前l～2 d、术后10～14 d行CTP检查，记录患者手术前后的大脑皮层、基底节和丘脑等部位的脑组织血流量、脑组织血容量、对比剂平均通过时间、到达峰值时间全部参数值并进行分析和比较．结果 颅骨修补术后患侧皮质CBF、CBV较术前显著增加，TTP缩短（P＜0.05）．两侧基底节和丘脑区在术前术后脑血流相关数值虽有所上升，但前后相比差异无统计学意义（P＞0.05）．结论 颅骨修补术后患侧皮质的脑血流量能获得改善，CT脑灌注可准确评估颅骨修补前后脑组织血流量的变化． |
| 关键词: ［关键词］CT灌注成像 脑血流量 颅骨修补术 |
| DOI： |
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| 基金项目:［基金项目］云南省卫计委卫生系统学科带头人基金资助项目（D-201221） |
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| Influence of 256-slice Spiral CT Perfusion Imaging on the Cerebral Blood Flow before and after Cranioplasty |
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ZHU Jian-ping1,2,3,4
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1.（1）Dept. of Radiology;2）Dept. of Neurosurgery，The 2nd Affiliated Hospital of Kunming Medical Universtiy，Kunming Yunnan 650101;3）Dept. of Radiology，Yun County People’s Hospital，Lincang Yunnan;4）The third Dept. of Urology，The 2nd Affiliated Hospital of Kunming Medical Universtiy， Kunming Yunnan 650101，China）
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| Abstract: |
| ［Abstract］Objective To evaluate changes in cerebral blood flow before and after cranioplasty by 256-slice Spiral CT perfusion imaging， and evaluate the effect of cranioplasty on the cerebral blood flow in patients with skull defect. Methods 256-slice spiral CT scan was performed in 20 cases with early cranioplasty surgery， CTP check time points were 1 to 2 days before and 10 to 14 days after cranioplasty surgery. We recorded the the CBF and CBV of the cortex， basal ganglia， and thalamus and other parts， MTT on rCBV， parameter values rCBF， MTT and 1TrP etc. and analyzed and compared. （RCBF， rCBV， MTT and TTP） Results The CBF of cortex after cranioplasty at injured side had statistically significant increase（P＜0.05）. The CBF of cortex，basic nuclei，thalamus on contrateral had no statistically significant difference． The cerebral blood flow on both sides of the basal ganglia and the thalamus was increased after surgery， but there was no significant difference between before and after surgery（P＞0.05） Conclusion Cranioplasty can significantly improve the ipsilateral cortex cerebral blood flow， and CT brain perfusion can accurately assess changes in brain tissue blood flow before and after cranioplasty. |
| Key words: ［Key words］CT perfusion imaging Cranioplasty Cerebral blood flow |