| 摘要: |
| ［摘要］目的 比较2种剂量的盐酸氨溴索对老年慢性阻塞性肺病急性加重期的疗效．方法 采用随机数字法将2012年5月至2014年5月在荆州市第一人民医院110 例老年慢性阻塞性肺病加重期患者分为小剂量组和大剂量组，小剂量组（56例）给予盐酸氨溴索30 mg，2 次/d，连续10 d 静脉滴注；大剂量组（54例）给予盐酸氨溴索60 mg /次，2 次/d，连续10 d 静脉滴注；并对2种剂量盐酸氨溴索的临床疗效进行观察．结果 大剂量盐酸氨溴索的临床总有效率（85.19%） 明显高于小剂量组（75.00%），2组存在差异有统计学意义（P＜0.05）；在不良反应方面，大剂量盐酸氨溴索的不良反应发生率（ 4.26%）与小剂量组（ 2.08%）相比未见统计学差异（P＞0. 05）．结论 大剂量盐酸氨溴索对老年慢性阻塞性肺病加重期疗效显著，安全性高． |
| 关键词: ［关键词］盐酸氨溴索 老年 患者慢性阻塞性肺病 急性加重期 疗效 |
| DOI： |
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| 基金项目:［基金项目］国家自然科学基金资助项目（30860286）；荆州市医疗卫生科技计划项目（2013-23） |
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| The Observation of Clinical Effect of Using Ambroxol in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
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HU Wei-hua
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（The first People’s Hospital of Jingzhou Affiliated to Yangtze University，Jingzhou Hubei 434000，Chian）
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| Abstract: |
| ［Abstract］Objective To compare the efficacy of two doses of ambroxol in the treatment of the elderly patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods A hundred and ten cases of the elderly patients with an acute exacerbation of COPD were divided into low-dose group and high-dose group. Low-dose group（56 cases）were given Ambroxol 30 mg，2 times per day for 10 day and high-dose group （54 cases）were given Ambroxol 60 mg，2 times per day for 10 days．Results The effective rate in high-dose group was significantly higher than that in low-dose group．Conclusion High-dose ambroxol has significant effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease. |
| Key words: ［Key words］Ambroxol Elderly patients Chronic obstructive pulmonary disease Exacerbation Efficacy |