| 摘要: |
| ［摘要］目的 探讨围手术期不同镇痛方式对结肠癌根治术患者细胞因子及皮质醇水平等的影响．方法 选择接受结肠癌根治术的患者86例，随机分为对照组及观察组，对照组仅接受静脉麻醉复合硬膜外阻滞，观察组在此基础上接受多模式复合镇痛，对术前及术后VAS评分、细胞因子及皮质醇水平进行测定．结果 观察组VAS评分术后1 d、2 d、3 d较对照组均有显著性下降 （P＜0.05）；观察组患者术后24 h IL-8、TNF-α较对照组显著下降 （P＜0.05）；术后48 h IL-6、IL-8、TNF-α较对照组显著下降 （P＜0.05）；观察组患者术后24 h Cor较对照组显著下性降 （P＜0.05）；术后48h Cor及ACTH较对照组显著下降 （P＜0.05）． 结论 围手术期多模式复合镇痛可通过减轻术后炎症状态及应激水平，有效缓解结肠癌根治术患者术后疼痛． |
| 关键词: ［关键词］多模式复合镇痛 皮质醇 炎性因子 结肠癌根治 |
| DOI： |
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| 基金项目:［基金项目］陕西省科技攻关基金资助项目（2011K32-06） |
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| Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer |
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YANG Jian－zhi1,2
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1.（1）Dept. of Anesthesiology，Central Hospital of Hanzhong，Hanzhong Shaanxi 723000;2）Medical School of Xi’an Jiaotong University， Xi’an Shaanxi 710004，China）
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| Abstract: |
| ［Abstract］Objective To investigate effects of multimodal analgesia on cytokines and cortisol levels in patients received surgical treatment for radical colon cancer. Methods Eighty-six patients with radical colon cancer treated with surgery were randomly divided into control group and observation group. The control group only received routine epidural anesthesia and the observation group received multimodal analgesia. Preoperative and postoperative VAS scores，cytokines and cortisol levels were measured. Results Compared with those of the control group，the following 5 indicators decreased significantly in the observation group including VAS scores of after 24 h，48 h，72 h， IL-8 and TNF-α after 24 h，IL-6，IL-8 and TNF-α after 48 h， Cor after 24h，and Cor and ACTH after 48 h（P＜0.05）. Conclusion Perioperative multi-mode analgesia helps relieve pain，stress and inflammatory cytokines among patients after the surgery for radical colon cancer. |
| Key words: ［Key words］Multimodal analgesia Cortisol Inflammatory factors Radical colon cancer surgery |