| 摘要: |
| ［摘要］目的 探讨阿德福韦酯与聚乙二醇干扰素α-2a联合治疗HbeAg 阳性慢性乙肝的疗效．方法 将122例HbeAg 阳性的慢性乙肝患者，随机分成2组，治疗组和对照组，每组61例治疗组，采用阿德福韦酯10 mg/d口服并联合聚乙二醇干扰素α-2a 180 ug，每周1 次皮下注射，治疗48 周；对照组，聚乙二醇干扰素α-2a 180u g 每周1 次皮下注射．结果 治疗24周及48周时在HbeAg 血清学转换率，HBV-DNA阴转率方面，2组相比差异有统计学意义（P＜0.05）．结论 阿德福韦酯与聚乙二醇干扰素α-2a联合治疗HbeAg 阳性慢性乙肝抗病毒效果优于单用聚乙二醇干扰素α-2a抗病毒效果. |
| 关键词: ［关键词］乙型肝炎 阿德福韦酯 聚乙二醇干扰素α-2a |
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| The Curative Effect of Polyethylene Glycol（peg）Interferon Alpha 2a Combined with Adefovir on HbeAg Positive Chronic Hepatitis B |
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YANG Yong－rui
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| Abstract: |
| ［Abstract］Objective To explore the curative effect of combination of polyethylene glycol interferon alpha 2 a and adefovir on HbeAg positive chronic hepatitis B．Methods 122 patients with HbeAg positive chronic hepatitis B were randomly divided into two groups: treatment group and control group. Patients in the treatment group were given oral administration of adefovir for 10 mg/d and subcutaneous injection of polyethylene glycol interferon alpha 2 a for 80 ug once a week for 48 weeks. Patients in the control group were only given subcutaneous injection of polyethylene glycol interferon alpha 2 a for 80 ug once a week for 48 weeks．Result There was statistically significant difference in the serology conversion rate of HbeAg and negative transfer rate of HBV-DNA in patients between two groups after treatment for 24 week and 48 week（P＜0.05）．Conclusion The antiviral effect of combination of adefovir and polyethylene glycol interferon alpha 2 a is better than single use of polyethylene glycol interferon alpha 2 a in treatment of HbeAg positive chronic hepatitis B. |
| Key words: ［Key words］Hepatitis B Adefovir Polyethylene glycol（peg） Interferon alpha α-2a |