| 摘要: |
| ［摘要］目的 探讨苯溴马隆对高尿酸血症的老年高血压合并糖尿病患者降尿酸治疗的疗效与安全性．方法 100例高尿酸血症的老年高血压合并糖尿病患者，规范控制血压、血糖，同时将患者分为研究组和对照组，研究组（低嘌呤饮食+苯溴马隆片50 mg，1次/d），对照组（低嘌呤饮食），疗程1 a．疗效及安全性指标为第 3、6、12 月血尿酸及肾功能、血压血糖检测，并系统评价有无皮疹、消化系统、神经系统、泌尿系统副作用．结果 （1）研究组治疗后第3、6、12月血尿酸水平明显低于治疗前及对照组（P＜0.01）；（2）研究组第6、12月24小时动态血压水平较治疗前及对照组明显改善，且动态血压达标率较治疗前提高（P＜0.05）；（3）2组治疗前后各检测点的肾功能、血糖等观察指标对比均无差异（P＞0.05）；（4）研究组治疗过程中有 2 例出现消化道症状，但能耐受，2组患者均未出现其他不良反应．结论 苯溴马隆片长期降尿酸治疗具有较好的疗效及良好的耐受性． |
| 关键词: ［关键词］高尿酸血症 降尿酸治疗 安全性 |
| DOI： |
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| 基金项目:［基金项目］云南省应用基础研究基金资助项目（2010CD123） |
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| The Clinical Efficacy and Safety of Decreasing Blood Uric Acid by Benzene Bromine Malone in Treatment of Hyperuricemia with Elderly Hypertension and Diabetes Mellitus |
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CHANG Song－ju
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（Dept. of Geriatrics，The Third People’s Hospital of Yunnan Province，Kunming Yunnan 650011，China）
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| Abstract: |
| ［Abstract］Objective To investigate the clinical efficacy and safety of decreasing blood uric acid by benzene bromine Malone in treatment of hyperuricemia with elderly hypertension and diabetes mellitus. Methods All 100 hyperuricemia in elderly patients with hypertension and diabetes mellitus received the standard drug treatments for blood pressure and blood sugar management. They were divided into study group（uric acid intervention group）and control group. Patients in the study group were given low purine diet and benzbromarone tablet （50 mg/day，course of 1 year）， while patients in the control group were only given low purine die. The indexes of the curative efect and security were the metabolism indexes such as blood uric acid and renal function as well as blood blood sugar and pressure. At the same time we evaluated systemly the side effects of rashes， digestive system， nervous system and urinary system. Results （1）In study group， 3 months， 6 months and 1 years after intervention， the serum uric acid levels were significantly lower than that before intervention and the control group（P＜0.01）. （2）The study group patients' ambulatory blood pressure was significantly lower than that before intervention and the control group after 6， 12months， meanwhile the study group patients' success rate of ambulatory blood pressure level was higher than themselves before the intervention after 6， 12months（P ＜0.05）. （3）The 2 groups of patients' metabolic indexes of related blood sugar and renal function had no difference at each testing point before and after the intervention. （4） Except 2 cases of digestive tract symptoms occurred but tolerated in the 2 groups， there had no other adverse reactions. Conclusion Long-term decreasing blood uric acid with benzene bromine Malone has good efficacy and tolerance. |
| Key words: ［Key words］Hyperuricemia Lowering uric acid treatment Safety |