| 摘要: |
| ［摘要］目的 探讨替硝唑单一使用和替硝唑联合乳酸杆菌活菌胶囊按不同方法联合使用治疗细菌性阴道病的临床疗效．方法 300例细菌性阴道病患者分为3组，A组单一给予替硝唑阴道栓1枚置入阴道深部，每晚1次，7 d为1个疗程；B组替硝唑阴道栓每晚1次，共7 d后每晚给予乳酸杆菌活菌胶囊1粒，再连续使用10 d， 17 d为1个疗程；C组替硝唑阴道栓和乳酸杆菌活菌胶囊同日内交替早晚使用，10 d为1个疗程．对比分析3种治疗方案的临床疗效及复发情况．结果 分析3组病例治疗后1周、1个月及3个月的各项实验室、临床指标可以发现，B组和C组远期疗效明显优于A组．3组治疗3个月后分析，A组有效率与B组比较，差异有统计学意义（P＜0.05）；A组有效率与C组比较，差异有统计学意义（P＜0.05）；B组与C组比较，差异无统计学意义（P＞0.05）．结论 在抗菌药物治疗的同时，使用微生态制剂重新让阴道内乳酸杆菌占优势，恢复阴道菌群平衡，可以从根本上防止细菌性阴道病的复发，是治疗该病的关键所在. |
| 关键词: ［关键词］细菌性阴道病 乳酸杆菌 替硝唑 |
| DOI： |
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| 基金项目:［基金项目］云南省应用基础研究基金资助项目（2014FB200） |
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| The Clinical Analysis of Three Kinds of Treatment Regimens for 300 Cases of Bacterial Vaginal Disease |
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ZHANG Wen
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（Kunming Maternal and Child Health Care Hospital，Kunming Yunnan 650031，China）
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| Abstract: |
| ［Abstract］Objective To study clinical efficacy of tinidazole alone and tinidazole combined with live- lactobacillus-bacteria capsule for bacterial vaginal disease according to the different methods．Methods 300 cases of bacterial vaginal disease were divided into three groups，group A:tinidazole was used alone into the vagina deep， one tablet each time，once every night for 7 days for a period of treatment；group B : tinidazole was used alone one tablet each time，once every night for 7 days ，after that live-lactobacillus bacteria capsule was used every night， one tablet each time for 10 days，continuous17 days for a period of treatment；Group C：tinidazole and live-lactobacillus bacteria capsule was used alternately on the morning and evening of the same day，10 days for a period of treatment．Then analysis of three kinds of clinical efficacy of treatment and relapse rate．Results We analyzed the laboratory and clinical indicators of three groups of cases after treatment 1 week，1 month，3 months ，and found that long curative effect in group B and C group was superior to group A. Three groups of treatment after 3 months，the difference between group A and group B was statistically significant（P < 0.05）；the difference between group C and group A was statistically significant （P < 0.05）；Group B and group C had no statistical significance（P > 0.05）．Conclusion The antibacterial drug combined with probiotics that make lactobacillus predominates at the same time， can restore vaginal flora balance， fundamentally prevent bacterial vaginal disease recurrence， is the key in treatment of the disease. |
| Key words: ［Key words］Bacterial vaginal disease Lactic acid bacteria Tinidazole |