| 摘要: |
| ［摘要］目的 分析X线辐射联合替莫唑胺化疗对胶质瘤CD1333、ABCG2表达的影响，为临床治疗提供参考．方法 以武警陕西总队医院在2013年1月至2015年2月人脑胶质瘤64例为观察对象，依照分级不同分为低级别组25例和高级别组39例，均给予X射线符合和替莫唑胺化疗，分析不同级别胶质瘤干预前后胶质瘤干细胞标志物CD133和ADCGG表达变化．结果 干预前，高级别组CD133表达（89.7％）和ABCG2表达（92.3％）均显著高于低级别组CD133表达（68.0％）和ABCG2表达（81.8％），P＜0.05，干预后高级别组和低级别组CD133表达和ABCG2表达均显著降低，P＜0.05，高级别组CD133表达（56.4％）和ABCG2表达（56.4％）均显著高于低级别组CD133表达（20.0％）和ABCG2表达（24.0％），P＜0.05，干预前后，CD133（r＝-0.782）和ABCG2（r＝-0.652）表达与细胞恶化程度呈现负相关，P＜0.05．结论 不同恶化程度胶质瘤细胞CD133和ABCG2表达存在一定差异，X线辐射联合替莫唑胺化疗治疗能够有效改善CD133和ABCG2表达． |
| 关键词: ［关键词］胶质瘤 替莫唑胺 CD133 ADCG2 |
| DOI： |
| 分类号: |
| 基金项目:［基金项目］广东省大学生创新实验计划资助项目（1212112006） |
|
| The Effect of the Treatment of X-ray Radiation Combined with Chemotherapy on the Expression of CD133 and ABCG2 in Glioma |
|
XU Hua1,2
|
|
1.（1）Dept. of Cancer Radiotherapy，The Armed Police Corps Hospital in Shaanxi Province， Xi’an Shannxi 710054;2）The Second Clinical Medical College，Southern Medical University，Guangzhou Guangdong 530030，China）
|
| Abstract: |
| ［Abstract］Objective To analyze the expression of Glioma CD133 and ABCG2 with the treatment of X-ray radiation combined with chemotherapy，and to provide a reference for clinical treatment. Methods Sixty-four patients with gliomas in hospital from January 2013 to February 2015 were selected， and divided into High-level group（39 cases）and the low-level group（25 cases）according to the grade of gliomas. Patients in two groups were given treatment of X-ray radiation combined and chemotherapy，the expression changes of Glioma stem cell marker ADCGG and CD133 before and after intervention were ompared between the two groups. Results CD133 expression （89.7%）and ABCG2 expression（92.3%）of High-level group were significantly lower than CD133 expression group（68.0%）and ABCG2 expression（81.8%） of low-level group before intervention（P＜0.05）. High-level group and the low level of CD133 and ABCG2 expression group were significantly decreased（P＜0.05）. CD133 expression（56.4%）and ABCG2 expression（56.4%）of High-level group were significantly lower than CD133 expression group（20.0%） and ABCG2 expression （24.0%） of low-level group after intervention（P＜0.05）. After the intervention，CD133（r = -0.782） and ABCG2 （r = -0.652） expression and cell deterioration degree had negative correlation（P＜0.05）．Conclusion There are some differences in the expression of CD133 and ABCG2 in glioma cells， and the expression of CD133 and ABCG2 could be improved by the combination of X-ray and radiation. |
| Key words: ［Key words］Glioma Temozolomide CD133 ADCG2 |