| 摘要: |
| ［摘要］目的 分析孕妇生殖道需氧菌、假丝酵母菌感染与胎膜早破的关系及其对母婴结局的影响．方法 对2012年1月至2014年1月在柳州市妇幼保健院进行产前检查并住院待产分娩的200例孕妇进行研究，其中早产胎膜早破组70例，足月胎膜早破组70例，正常妊娠组60例；对所有入选病例进行生殖道分泌物需氧菌和假丝酵母菌检测，分析各组致病菌感染情况及其对母婴结局的影响．结果 早产胎膜早破组及足月胎膜早破组产妇生殖道致病菌感染率显著高于正常分娩组，早产胎膜早破组致病菌感染率也高于足月胎膜早破组，差异均具有统计学意义（P＜0.05）．将假丝酵母菌和需氧菌检测阳性者作为感染组，两者均阴性者作为未感染组，2组在胎儿早产率、剖宫产率、新生儿感染、低出生体重率以及新生儿疾病率方面差异均具有统计学意义（P＜0.05）．进一步比较假丝酵母菌感染和需氧菌感染分别对母婴结局影响，结果显示2组感染患者在胎儿早产、产妇剖宫产率、新生儿感染、胎儿窘迫、新生儿疾病以及围生儿死亡等方面差异无统计学意义（P＞0.05）；而2组低出生体重率比较差异均具有统计学意义（P＜0.05）．结论 胎膜早破与孕妇假丝酵母菌和需氧菌感染密切相关，对孕妇生殖道致病菌检查，采取有效的抗菌治疗，可降低胎膜早破发生率，改善母婴结局． |
| 关键词: ［关键词］胎膜早破 假丝酵母菌 需氧菌 妊娠结局 |
| DOI： |
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| 基金项目:［基金项目］国家级临床重点专科建设项目（卫规财函[2011]1号） |
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| Influence of Candida and Aerobic Bacteria Infection on Maternal and Neonatal Outcomes of Premature Rupture of Membranes |
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YI Hai-ping1,2
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1.（1）Dept. of Gynaecology，Liuzhou Maternal and Child Health-Care Hospital，Liuzhou Guangxi 545001;2） Dept. of Gynaecology，West China Second Hospital，Sichuan University，Chengdu Sichuan 610041，China）
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| Abstract: |
| ［Abstract］Objective To analyze the relationship between premature rupture of membranes and Candida and aerobic bacteria infection， and investigate the influence of Candida and aerobic bacteria infection on pregnancy outcomes. Methods 200 pregnant women in Liuzhou maternal and child health-care hospital from Jan 2012 to Jan 2014 were enrolled in this study. They were divided into three groups，70 patients in preterm premature rupture of membrane group（PPROM group），70 patients in term premature rupture of membrane group（TPROM group） and 60 cases in normal pregnancy group. The cervical secretions were collected to detect Candida and aerobic bacteria infection. Effect of Candida and aerobic bacteria infection on pregnancy outcomes was analyzed. Results Pathogenic bacteria infection rates of PPROM group and TPROM group were higher than that of normal pregnancy group， pathogenic bacteria infection rates of PPROM group was higher than that of pathogenic bacteria infection rates of TPROM group，and the difference were all significant（P < 0.05）. The patients with Candida and aerobic bacteria infection were enrolled as infected group， and patients without Candida and aerobic bacteria infection were enrolled as uninfected group. The rates of premature birth， cesarean section， neonatal infection，low birth weight and perinatal diseases in infected group were significantly higher than those in uninfected group（P < 0.05）. Pregnancy outcomes were compared between patients with Candida infection and aerobic bacteria infection. As the results， there were no significantly differences in the rates of premature birth， cesarean section， neonatal infection， fetal distress， perinatal diseases and perinatal death（P > 0.05）， but there was a significantly difference in the rate of low birth weight between patients with Candida infection and aerobic bacteria infection（P < 0.05）. Conclusion Candida and aerobic bacteria infection are closely related to poor pregnancy outcomes of premature rupture of membranes. Examination of pathogenic microorganism and effective antibiotic treatment can reduce the rate of premature rupture of membrane and improve maternal and neonatal outcomes. |
| Key words: ［Key words］Premature rupture of membrane Candida Aerobic bacteria Pregnancy outcomes |