| 摘要: |
| ［摘要］目的 探讨VDR基因FokI位点单核苷酸多态性与2型糖尿病肾病的相关性．方法 应用TaqMan 荧光探针技术，对235例2型糖尿病患者其中正常白蛋白尿（DKD0）组82例，微量白蛋白组（DKD1）组66例，大量白蛋白尿组（DKD2）组 87例和86例健康对照者（NGT）组的VDR基因FokI位点SNP进行检测，比较和分析各组间基因型频率和等位基因频率以及相关临床资料．结果 （1）总体人群FokI位点CC、TC、TT基因型频率分别为25.23%、53.27%、21.50%，等位基因C和T频率分别为51.87%及48.13%；（2）NGT组、DM组及DKD各组间基因型频率及等位基因频率未显示统计学差异（P＞0.05）；（3）Logistic回归分析提示FokI位点C等位基因可能与T2DKD 发生无关（OR＝2.040，P＝0.05），但与T2DKD进展有关（OR＝4.741，P＝0.004）．结论 VDR基因 FokI位点C等位基因可能是T2DKD 进展的危险因素． |
| 关键词: ［关键词］维生素D受体基因 单核苷酸多态性 2型糖尿病 糖尿病肾病 慢性肾脏病 25羟维生素D |
| DOI： |
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| 基金项目:［基金项目］云南省科技厅-昆明医科大学联合专项基金资助项目（2012FB085）；云南省教育厅科学研究基金资助项目（2012C020） |
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| The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease |
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XIANG Qian1,2
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1.（1）Dept. of Endocrine，The Fifth Affiliated Hospital of Kunming Medical University/ Yunnan Honghe Diannan Central Hospital，Gejiu Yunnan 661000;2）Dept. of Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China）
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| Abstract: |
| ［Abstract］Objetive To investgate the correlation of Vitamin D receptor gene FokI single nucleotide polymorphism with diabetic kidney disease in type 2 diabetic patients．Methods The single nucleotide polymorphism of VDR gene in 235 type 2 diabetes， [including 82 normal albuminuria（DKD0 group），66 microalbuminuria（DKDl group ）and 87 macroalbuminuria（DKD2 group）]and 86 normal controls were detected by TaqMan real-time polymerase chain reaction. The genotype frequency and allele frequency and relative clinical data were compared among groups. Results（1）FokI CC，TC，TT genotype frequencies were 25.23%， 53.27%，21.50%，allele C and allele T frequencies were 51.87% and 48.13% in overall populations. （2）The genotype frequency and allele frequency among groups had no statistically significant difference（P＜0.05）. （3） Logistic multiple regression analysis showed that FokI C allele was not related to T2DKD occurrence（OR=2.040，P＝0.05），but was related to T2DKD development（OR＝4.741，P＝0.004）. Conclusion VDR gene FokI C allele is associated with the risk of T2DKD development. |
| Key words: ［Key words］Vitamin D receptor gene Single nucleotide polymorphism Type 2 diabetes mellitus Diabetic kidney disease Chronic kidney disease 25-hydroxy-vitamin D |