| 摘要: |
| ［摘要］目的 探讨不同剂量及使用方法下埃索美拉唑治疗非静脉曲张上消化道出血的效果．方法 收集曲靖市第一人民医院2014年8月至2015年10月以ANVUGB收住消化内科90例患者，在联合使用奥曲肽及其他基础治疗相同的前提下，接受埃索美拉唑80 mg静脉推注后8 mg/min持续泵入72 h的患者纳为治疗组（45例）；将接受埃索美拉唑40 mg间隔12 h静脉滴注，连续治疗3 d的患者为对照组（45例），分析上述两种不同的治疗方式治疗急性非静脉性上消化道出血的效果． 结果 治疗组及对照组中分别统计了男性、女性、年龄大于60岁以上者、血色素低于70.0 g以下者中2组中有效的病例数，差异有统计学意义（P＜0.05），显示不同细化分组组别中治疗组有效病例数高于对照组； 治疗组平均住院天数为（7.3±2.4）d，对照组平均住院天数为（9.5±3.6）d，2组差异有统计学意义（P＜0.05），治疗组住院天数较对照组短．输血量统计显示治疗组输血量较对照组少．结论 在联合使用奥曲肽前提下，埃索美拉唑80 mg静脉推注后以8 mg/min剂量持续泵入方法治疗急性非静脉曲张上消化道出血止血效果更佳、住院时间更短、临床输血量更少，有临床推广的价值． |
| 关键词: ［关键词］埃索美拉唑 非静脉曲张上消化道大出血 疗效 |
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| 基金项目:［基金项目］云南省科技厅-昆明医科大学应用基础研究联合专项基金（2013FB206） |
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| Clincal Effect of Different Doses of Esomeprazole in Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding |
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ZHAO Li-dong1,2
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1.（1）Dept. of Digestive Diseases，The First People’s Hospital of Qujing，Qujing Yunnan 655000;2.２）Dept. of Digestive Diseases，The First People’s Hospital of Yunnan Province，Kunming Yunnan 650032，China）
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| Abstract: |
| ［Abstract］Objective To investigate the clinical effect of different doses of esomeprazole in treatment of nonvariceal upper gastrointestinal bleeding（ANVUGIB）．Methods We collected the data of 90 patients with ANVUGIB admitted in our hospital from August 2014 to October 2015. The 90 patients were divided into 2 groups: treatment group and control group. Patients in both group were given the combination of Octreotide and other treatment，patients in the treatment group were given continuous pumping of 8 milligrams of esomeprazole per minute for 72 hours after intravenous injection of 80 mg of esomeprazole， patients in the control group were given intravenous instillation of 40 mg of esomeprazole every 12 hours. Then we compared the clinical effect between two groups. Results In the two groups，we statistically analyzed the number of effective cases according to the gender（male and femal），age over 60 years old， and the hemoglobin less than 70.0 grams，there was a statistical significant difference （P < 0.05），suggesting that the number of effective cases in the treatment group was higher than that in the control group. The average hospitalization days of patients in the treatment group and the control group was （7.3 + 2.4） days and （9.5 + 3.6） days， respectively，there was a statistical significant difference（P < 0.05）. The blood transfusion volumes of patients in the treatment group was less than that in the control group.Conclusion On the basis of octreotide treatment，continuous pumping of 8 milligrams of esomeprazole per minute after intravenous injection of 80 mg of esomeprazole has better hemostatic effect， shorter hospitalization time， and less blood transfusion volume in treatment of nonvariceal upper gastrointestinal bleeding， so it is worthy of clinical promotion. |
| Key words: ［Key words］Esomeprazole Nonvariceal upper gastrointestinal bleeding Curative effect |